All Hands Meeting December 12-13 2013

HIVE Center All Hands Meeting

December 12-13 2013

Faculty Club, The Scripps Research Institute

Program Day 1

8:00—8:45 Continental Breakfast

9:00—9:15 Olson

Welcome, Introductions, Plan for the Meeting

9:15—9:30 Goodsell / HIVE

Visualizing the Immature Virion

9:30—10:00 Tainer/ Perry/ Elder

SAXS studies of HIV Pr and Gag

10:00—10:30 Kvaratskelia/ Engelman/ Levy / Finn

HIV-1 Integrase Interactions with LEDGF/p75”

10:30—11:00 Coffee Break and Poster Session

11:00 —11:30 Olson/ Levy/ Kvaratskelia/ Fuchs

Enhanced Virtual Screening and Free Energy Evaluation of HIV Integrase Interactions

11:30 —12:00 Torbett/ Levy

Correlated Gag Mutations in the Evolution of Drug Resistance

12 Noon – 1:30 Lunch (box lunches provided)

1:30 — 2:00 Belew / HIVE

Creating a HIVE Database and Repository

2:00 —2:30 Sarafianos/ Arnold/ Parniak

Rilpivirine Inhibition of Initiation of HIV RT: A Pre-steady State Kinetics Approach

“Capsid-Targeting Small Molecules Blocking HIV through Novel Mechanism of Action”

2:30 – 3:00 Arnold/ Marcotrigiano

"Studies of the HIV-1 RT/vRNA/tRNA initiation complex, expression and purification of foamy virus and HIV-1 Pol polyproteins, and progress with a lentiviral system for expressing complex human and viral proteins"

3:00 – 3:45 Coffee Break and Poster Session

3:45 – 4:15 Fuchs/ Arnold/ Kvaratskhelia

"Fragment-based drug design targeting the allosteric LEDGF/p75 site of HIV-1 integrase"

4:15 – 4:45 Griffin/ et. al.

HDX/MS, NMR, and HTS HIVE Core Activities

4:45 – 5:15 Lyumkis

"Heterogeneous macromolecules analyzed by single particle electron microscopy"

5:15 – 6:00 Wine Break/ posters

6:00 —HIVE Center Meeting Dinner (TSRI Faculty Club)



9:10—9:40 Parniak

Proteolytic maturation of heterodimeric p66/p51 HIV reverse transcriptase”

9:40—10:00 Open Discussion on Collaborations, SAB Feedback …

10:00—10:30 Coffee Break, Poster session

10:30—noon Breakout Session I

12:00—1:30 Lunch (box lunches provided)

1:30—3:00 Breakout Session II

3:00—3:30 Coffee Break

3:30—5:00 Discussion of Breakout Sessions, work products and future plans

5:00—Adjourn (Dinner plans on your own)